Melfa is a town in Accomack County on the Eastern Shore of Virginia in the United States. The population was 408 at the 2010 census.Melfa is located at 37°38′59″N 75°44′29″W / 37.64972°N 75.74139°W / 37.64972; -75.74139.According to the United States Census Bureau, the town has a total area of 0.3 square miles, all of it land.As of the census of 2000, there were 450 people, 183 households, and 131 families residing in the town. The population density was 1,654.6 people per square mile. There were 205 housing units at an average density of 753.8 per square mile. The racial makeup of the town was 82.44% White, 15.78% African American, 0.22% Native American, 1.33% from other races, and 0.22% from two or more races. Hispanic or Latino of any race were 2.22% of the population.There were 183 households out of which 32.2% had children under the age of 18 living with them, 60.1% were married couples living together, 10.4% had a female householder with no husband present, and 28.